Can I disinherit my children in my will?

The first thing is to consult with a lawyer who specializes in inheritance law because the laws vary quite a bit depending on your autonomous community. In general, in Spain you're free to make your will, but there are limits: your children have the right to a portion of the inheritance (the forced share), so technically you can't disinherit them completely without a justified legal reason like abandonment or serious abuse. It's best for a professional to explain exactly what options you have depending on your specific situation and where you live.