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Don't just throw it loose in your backpack with other stuff because cables and keys will scratch it without you even thinking about it. Best bet is a decent case plus a padded pouch or a separate little bag inside the backpack, so you keep the phone away from everything else. If the backpack drops or takes a hit, that padding saves you from a heart attack and probably a broken screen too.
I agree that a case is necessary, but honestly it depends on how much you care about your phone and how accident-prone you are. If your backpack is one of those that you bang against everything, a thick case plus a padded sleeve will save your iPhone's life, but if your backpack is more careful and organized, a regular case and just not putting keys or sharp things in the same compartment will keep it safe. What kind of backpack do you use and how careful are you with your gear?
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