Do you actually want to make the most of the night or are you more worried about not feeling sad? Because those are different things.
I think what really makes the difference is setting up something you'd actually enjoy doing even if it wasn't New Year's Eve. Like, some of the comments above suggest the standard stuff (movie, good food), which is valid, but it can feel kind of empty if you're not really into it. Think of something you've been putting off when you have other obligations: a game that's on your list, reorganizing a room, learning something new on your phone, binge-watching a series everyone keeps recommending. The thing is to have something that really demands your attention and that you actually like, you know? Midnight comes naturally in the middle of it all.
There's also the more chill side: get yourself a good snack, put on a playlist you like (doesn't have to be party music), and settle somewhere comfortable. If you want to do something social without leaving home, call someone to play online or video chat during the night. It's not the same as being together in person, but it breaks that silence. And honestly, there's something nice about being at peace inside your house while everyone's in chaos out there. You control the pace of your night.