Feather plucking in African greys is almost always a sign that something needs immediate attention, and you should get her to an avian vet as soon as possible. While stress and behavioral issues do cause this, so do medical problems like mites, fungal infections, nutritional deficiencies, and hormonal imbalances. Three weeks is already a meaningful window, and African greys in particular are prone to serious underlying conditions when they start self-mutilating. A vet can rule out skin parasites, infections, and metabolic issues through examination and sometimes blood work. Don't wait on this one.
That said, once medical stuff is cleared, stress is definitely real for these birds. African greys are incredibly intelligent - we're talking problem-solving abilities comparable to a 4-6 year old human - and they need serious mental stimulation and social interaction. They live 40-60 years in captivity, sometimes longer, so they're essentially your companion for decades. Boredom, isolation, changes in routine, or even things like inadequate sleep (they need around 10-12 hours of uninterrupted dark time) can trigger plucking. If the vet finds nothing medical, you'd want to look hard at her environment, enrichment, diet, and whether there have been any changes recently.
The cage setup matters too. Your grey needs a space that's large enough for real movement, not just perching. Most people underestimate how much room these birds actually need. In the meantime, keep detailed notes about when the plucking happens, what she's eating, light exposure, any loud noises or household disruptions - basically anything that might be relevant. This info will help your vet figure out what's going on.